GANA PATCH-KFDA approved (wound dressing)

    KFDA and FDA  approved product




    GANA PATCH     is  bio cellulose sheet
    containing cross linked hyaluronic acid



    Bacterial cellulose


    Main use of GANA PATCH is open wound covering






    GANA PATCH is completely non allergenic and do not cause
    any inflammation even in body




    GANA PATCH   

     wound covering materials 
    Development objective


     It is impossible to cure patients who has widespread damage skin so far.

    What is difference,
       - As soon as applied to patient
         GANA PATCH can  keep moisturizing from evaporation
       - Prevent infection
       - Mechanical -chemical protection
    -Absorb exudate
    -Reduce pain
    -Components  in GANA PATCH stimulate the collgen synthesis of soft tissue defect so that there will be no more exudate

    -High concentration Cross linked hyaluronic acid gel absorb watery content from wound .
      stuff soft tissue defect immediately and keep moisturizing from evaporation

    -Do not need to change dressing every day. Change GANA PATCH every week
     

                         
     In case of major wound. accompanied by soft tissue loss and epithelium damage. GANA PATCH  
     includes active ingredients for epithelial cell and soft tissues regeneration.

    Not necessary of skin graft

     After an immediate indication, immediate  recovery of skin functions from burn injuries or skin loss.
    Regeneration soft tissue and epithelium
    Bio cellulose itself replaces soft tissue mechanically
    Not necessary of wound dressing
    -once apply to any wound  you just keep watching until you see healed wound  


    Progress

    Bio cellulose itself does not cause any immune side effect and any other response in the body.
    The epithelial cell migrates to  GANA PATCH and then GANA PATCH may be positioned under the epidermis.


     

    GANA PATCH Package Contents
    1. GANA PATCH sheet
    sheet size 15 X 10cm


     


    WHAT IS THE IDEAL wound dressing?

    Able to resist infection
    Able to prevent water loss
    Able to withstand the shear forces
    Cost effective
    Widely available
    Long shelf life and easy to store
    Lack of antigenicity
    Flexible in thickness
    Durable with long-term wound stability
    Can be conformed to irregular wound surfaces and
    Easy to be secured and applied


     

    Bacterial cellulose


    Bacterial cellulose is an organic compound with the formula (C
    6    H
    10    O
    5    )
    n    ) produced by certain types of bacteria. While cellulose is a basic structural material of most plants, it is also produced by bacteria, principally of the genera Acetobacter, Sarcina ventriculi and Agrobacterium. Bacterial, or microbial, cellulose has different properties from plant cellulose and is characterized by high purity, strength, moldability and increased water holding ability.[1] In natural habitats, the majority of bacteria synthesize extracellular polysaccharides, such as cellulose, which form protective envelopes around the cells. While bacterial cellulose is produced in nature, many methods are currently being investigated to enhance cellulose growth from cultures in laboratories as a large-scale process. By controlling synthesis methods, the resulting microbial cellulose can be tailored to have specific desirable properties. For example, attention has been given to the bacteria Acetobacter xylinum due to its cellulose’s unique mechanical properties and applications to biotechnology, microbiology, and materials science. Historically, bacterial cellulose has been limited to the manufacture of Nata de coco, a South-East Asian food product.[2] With advances in the ability to synthesize and characterize bacterial cellulose, the material is being used for a wide variety of commercial applications including textiles, cosmetics, and food products, as well as medical applications. Many patents have been issued in microbial cellulose applications and several active areas of research are attempting to better characterize microbial cellulose and utilize it in new areas.[1]

    SEM findings of
    Bacterial cellulose

    Bacterial cellulose aperture is so small
    Any kinds of cells and bacteria can not pass through
    only water can pass through

    And surface area of bacterial cellulose is so wide
    Biocellulose  can hold  a lot of water inside

    In conclusion
    Biocelluose can protect any kinds of infection
     Absorb exudate from wound and evaporate water outward

    ••Hyaluronic acid (HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfatedglycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large, with its molecular weight often reaching the millions.[2] One of the chief components of the extracellular matrix, hyaluronan contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors.[3]
    •The average 70 kg (154 lb) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (degraded and synthesized) every day.[4] Hyaluronic acid is also a component of the group A streptococcal extracellular capsule,[5] and is believed to play a role in virulence.[6][7]
    •


    How to use
    1. Sterilize wound

    2.Take out GANA PATCH sheet out of bottle. use sterile technique
    3.Cover GANA PATCH sheet on the wound . 
    4.Cover GANA PATCH sheet with sterile gauze
    5. change GANA PATCH every week


    So you do not have to clean the wound every day
    just check wound whether there is infection