GANA PATCH-KFDA approved (wound dressing)

KFDA and FDA  approved product

 is  bio cellulose sheet
containing cross linked hyaluronic acid

Bacterial cellulose

Main use of GANA PATCH is open wound covering

GANA PATCH is completely non allergenic and do not cause
any inflammation even in body


 wound covering materials 

Development objective

 It is impossible to cure patients who has widespread damage skin so far.

What is difference,
   - As soon as applied to patient
     GANA PATCH can  keep moisturizing from evaporation
   - Prevent infection
   - Mechanical -chemical protection
-Absorb exudate
-Reduce pain
-Components  in GANA PATCH stimulate the collgen synthesis of soft tissue defect so that there will be no more exudate

-High concentration Cross linked hyaluronic acid gel absorb watery content from wound .
  stuff soft tissue defect immediately and keep moisturizing from evaporation

-Do not need to change dressing every day. Change GANA PATCH every week

 In case of major wound. accompanied by soft tissue loss and epithelium damage. GANA PATCH  
 includes active ingredients for epithelial cell and soft tissues regeneration.

Not necessary of skin graft

 After an immediate indication, immediate  recovery of skin functions from burn injuries or skin loss.
Regeneration soft tissue and epithelium
Bio cellulose itself replaces soft tissue mechanically
Not necessary of wound dressing
-once apply to any wound  you just keep watching until you see healed wound  


Bio cellulose itself does not cause any immune side effect and any other response in the body.

The epithelial cell migrates to  GANA PATCH and then GANA PATCH may be positioned under the epidermis.


GANA PATCH Package Contents
1. GANA PATCH sheet
sheet size 15 X 10cm


WHAT IS THE IDEAL wound dressing?

Able to resist infection
Able to prevent water loss
Able to withstand the shear forces
Cost effective
Widely available
Long shelf life and easy to store
Lack of antigenicity
Flexible in thickness
Durable with long-term wound stability
Can be conformed to irregular wound surfaces and
Easy to be secured and applied


Bacterial cellulose

Bacterial cellulose is an organic compound with the formula (C
) produced by certain types of bacteria. While cellulose is a basic structural material of most plants, it is also produced by bacteria, principally of the genera Acetobacter, Sarcina ventriculi and Agrobacterium. Bacterial, or microbial, cellulose has different properties from plant cellulose and is characterized by high purity, strength, moldability and increased water holding ability.[1] In natural habitats, the majority of bacteria synthesize extracellular polysaccharides, such as cellulose, which form protective envelopes around the cells. While bacterial cellulose is produced in nature, many methods are currently being investigated to enhance cellulose growth from cultures in laboratories as a large-scale process. By controlling synthesis methods, the resulting microbial cellulose can be tailored to have specific desirable properties. For example, attention has been given to the bacteria Acetobacter xylinum due to its cellulose’s unique mechanical properties and applications to biotechnology, microbiology, and materials science. Historically, bacterial cellulose has been limited to the manufacture of Nata de coco, a South-East Asian food product.[2] With advances in the ability to synthesize and characterize bacterial cellulose, the material is being used for a wide variety of commercial applications including textiles, cosmetics, and food products, as well as medical applications. Many patents have been issued in microbial cellulose applications and several active areas of research are attempting to better characterize microbial cellulose and utilize it in new areas.[1]

SEM findings of
Bacterial cellulose

Bacterial cellulose aperture is so small
Any kinds of cells and bacteria can not pass through
only water can pass through

And surface area of bacterial cellulose is so wide
Biocellulose  can hold  a lot of water inside

In conclusion
Biocelluose can protect any kinds of infection
 Absorb exudate from wound and evaporate water outward

Hyaluronic acid (HAconjugate base hyaluronate), also called hyaluronan, is an anionicnonsulfatedglycosaminoglycan distributed widely throughout connectiveepithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large, with its molecular weight often reaching the millions.[2] One of the chief components of the extracellular matrix, hyaluronan contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors.[3]
The average 70 kg (154 lb) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (degraded and synthesized) every day.[4] Hyaluronic acid is also a component of the group A streptococcal extracellular capsule,[5] and is believed to play a role in virulence.[6][7]

How to use
1. Sterilize wound

2.Take out GANA PATCH sheet out of bottle. use sterile technique
3.Cover GANA PATCH sheet on the wound . 
4.Cover GANA PATCH sheet with sterile gauze
5. change GANA PATCH every week

So you do not have to clean the wound every day

just check wound whether there is infection