GANA PATCH (bed sore and burn dressing)

GANA PATCH is  bio cellulose sheet
containing cross linked hyaluronic acid



Bacterial cellulose


Main use of GANA PATCH is open wound covering

Burn dressing and bed sore





GANA PATCH is completely non allergenic and do not cause
any inflammation even in body




GANA PATCH   

 wound covering materials 

Development objective


 It is impossible to cure patients who has widespread damage skin so far.

What is difference,
   - As soon as applied to patient
     GANA PATCH can  keep moisturizing from evaporation
   - Prevent infection
   - Mechanical -chemical protection
-Absorb exudate
-Reduce pain
-Components  in GANA PATCH stimulate the collgen synthesis of soft tissue defect so that there will be no more exudate

-High concentration Cross linked hyaluronic acid gel absorb watery content from wound .
  stuff soft tissue defect immediately and keep moisturizing from evaporation

-Do not need to change dressing every day. Change GANA PATCH every week
 

                     
 In case of major burns is accompanied by soft tissue loss and epithelium damage. GANA PATCH  
 includes active ingredients for epithelial cell and soft tissues regeneration.

Not necessary of skin graft

 After an immediate indication, immediate  recovery of skin functions from burn injuries or skin loss.
Regeneration soft tissue and epithelium
Bio cellulose itself replaces soft tissue mechanically
Not necessary of wound dressing
-once apply to any wound  you just keep watching until you see healed wound  


Progress


Bio cellulose itself does not cause any immune side effect and any other response in the body.

The epithelial cell migrates to  GANA PATCH and then GANA PATCH may be positioned under the epidermis.


 

GANA PATCH Package Contents
1. GANA PATCH sheet
sheet size 15 X 10cm


 


WHAT IS THE IDEAL wound dressing?

Able to resist infection
Able to prevent water loss
Able to withstand the shear forces
Cost effective
Widely available
Long shelf life and easy to store
Lack of antigenicity
Flexible in thickness
Durable with long-term wound stability
Can be conformed to irregular wound surfaces and
Easy to be secured and applied


 

Bacterial cellulose


Bacterial cellulose is an organic compound with the formula (C
6
H
10
O
5
)
n
) produced by certain types of bacteria. While cellulose is a basic structural material of most plants, it is also produced by bacteria, principally of the genera Acetobacter, Sarcina ventriculi and Agrobacterium. Bacterial, or microbial, cellulose has different properties from plant cellulose and is characterized by high purity, strength, moldability and increased water holding ability.[1] In natural habitats, the majority of bacteria synthesize extracellular polysaccharides, such as cellulose, which form protective envelopes around the cells. While bacterial cellulose is produced in nature, many methods are currently being investigated to enhance cellulose growth from cultures in laboratories as a large-scale process. By controlling synthesis methods, the resulting microbial cellulose can be tailored to have specific desirable properties. For example, attention has been given to the bacteria Acetobacter xylinum due to its cellulose’s unique mechanical properties and applications to biotechnology, microbiology, and materials science. Historically, bacterial cellulose has been limited to the manufacture of Nata de coco, a South-East Asian food product.[2] With advances in the ability to synthesize and characterize bacterial cellulose, the material is being used for a wide variety of commercial applications including textiles, cosmetics, and food products, as well as medical applications. Many patents have been issued in microbial cellulose applications and several active areas of research are attempting to better characterize microbial cellulose and utilize it in new areas.[1]


Hyaluronic acid (HAconjugate base hyaluronate), also called hyaluronan, is an anionicnonsulfatedglycosaminoglycan distributed widely throughout connectiveepithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large, with its molecular weight often reaching the millions.[2] One of the chief components of the extracellular matrix, hyaluronan contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors.[3]
The average 70 kg (154 lb) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (degraded and synthesized) every day.[4] Hyaluronic acid is also a component of the group A streptococcal extracellular capsule,[5] and is believed to play a role in virulence.[6][7]



Poly(L-lactide) is a biodegradable material with good bio-absorbability and bio-compatibility.

After degradation in the body, PLLA products are excreted by metabolism and thus has no harmful side effects to the

human body. It is for these reasons that PLLA products are currently widely used in the field of medicine, such as for

one-time infusion equipment, medical surgical suture, drug delivery carriers, tissue engineering scaffolds, bone anchors,

injectable microcapsules, microspheres, implants, elastomer materials for organ support, etc.

How to use
1. Sterilize wound

2.Take out GANA PATCH sheet out of bottle. use sterile technique
3.Cover GANA PATCH sheet on the wound . 
4.Cover GANA PATCH sheet with sterile gauze
5. change GANA PATCH every week


So you do not have to clean the wound every day

just check wound whether there is infection

CASE REPORT
GANA DERM
Electirical  burn


Post burn injury DAY # 1

 

# 30years old female

Got 3rd  degree electrical  burn

 on popliteal fossa

Size was 15cm X 5xm

 

The full skin necrosis could be seen

After debriment of dead skin

Fat tissue was seen

 

She was supposed to be hospitalized for many month

And she needed skin graft

 

But she refused to be hospitalized

Once she was hospitalized

She must have lost job ,suffered terrible pain and lost big money for skin graft

So we start to treat her with new burn dressing material GANADERM

Post burn injury DAY # 1

 

With conventional treatment

She was supposed to suffer from terribly painful escharectomy and

Daily dressing to clean the burn wound

 

But with GANADERM

No painful treatment anymore

GANA DERM absorb exudate

Consequently prohibit the formation of eschar and exudate discharge

 

GANADERM also contain dermal filler contents so that fill the empty space of 3rddegree burn

Post burn injury DAY # 1wks

 

 

We used one ganadermevery week

We  sterilized the wound and covered GANADERM

Then we observed her for a week

She was not hospitalized

And she did not suffer from painful

Escharectomy

 

 

As you can  see there is no eschar and no pus discharge

GANADERM sheet is made of bio cellulose

This bio cellulose specially made for burn ,absorb exudate

Post burn injury DAY # 3wks

 

 

As you can see there is epithelization in the middle of wound

Post burn injury DAY # 4wks

 

 

As you can see there is epithelization in the middle of wound

 

And marginal growth of skin

 

Also we could see lower exudate discharge

 

Still we changed one GANADERM

In a week

 

 

Post burn injury DAY # 5wks

 

 

There was remarkable epithelization from the margin

 

This epithelizationspeed was very fast 

 

 

 

Post burn injury DAY # 6wks

 

 

In 6wks

She was cured from 3rd degree burn without hospitalization

Without skin graft

 

 

The complete wound healing

Epithelizationcould be seen